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Gainetdinov Lab
How do animals make, use, and destroy small RNAs?
In eukaryotes, small (18–33 nt) RNAs direct Argonaute proteins to silence complementary RNA targets. Different classes of small RNAs regulate host gene expression, fight viral infections, and silence transposons. We use genetics in mice and flies and biochemical approaches to understand the biological roles of small RNA-mediated gene regulation.
Post-transcriptional gene regulation
Our lab uses experimental and computational quantitative approaches to provide a transcriptome-wide, time-resolved perspective of RNA turnover pathways in animals. We apply metabolic labeling and high-throughput sequencing to reveal how the kinetics of various RNA turnover steps and their regulation influence steady-state transcript levels.
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