Gainetdinov Lab
Selected publications
Divergent regulatory impacts of endogenous siRNAs on host mRNAs in testis of closely related species
Zamani M, Jarva T, Moukheiber H, Kloss-Schmidt A, Ajaykumar N, Lin CJ, Chalouh-Hara B, Moskowitz A, Steinhauer J, Lai EC, Gainetdinov I
bioRxiv 2026; doi.org/10.64898/2026.05.18.725984
Cleavage of mRNAs by a minority of pachytene piRNAs improves sperm fitness
Cecchini K, Zamani M, Ajaykumar N, Vega-Badillo J, Bagci A, Bailey S, Zamore PD, Gainetdinov I
Nature 2026; 652: 508–516
Absolute Quantification of Mammalian MicroRNAs for Therapeutic RNA Cleavage and Detargeting
Kraus C, Wang J, Zheng H, Broderick J, Ajaykumar N, Zamani M, Mengqi Y, Cecchini K, Liang SQ, Kolumba O, Chase K, Lee J, Xue W, Sontheimer E, Gainetdinov I
RNA 2025; 31:1081-1090
Relaxed targeting rules help PIWI proteins silence transposons
Gainetdinov I, Vega-Badillo J, Cecchini K, Bagci A, Colpan C, De D, Bailey S, Arif A, Wu PH, MacRae IJ, Zamore PD
Nature 2023; 619: 394–402
Venkei ZG*, Gainetdinov I*, Bagci A, Starostik MR, Choi CP, Fingerhut JM, Chen P, Balsara C, Whitfield TW, Bell GW, Feng S, Jacobsen SE, Aravin AA, Kim JK, Zamore PD, Yamashita YM. *co-first authors
Nat Cell Biol 2023; 25:1495–1505
Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability
Gainetdinov I, Colpan C, Cecchini K, Arif A, Jouravleva K, Albosta P, Vega-Badillo J, Lee Y, Özata DM, Zamore PD
Mol Cell 2021; 81: 4826–4842
Gainetdinov I*, Colpan C*, Arif A, Cecchini K, Zamore PD. *co-first authors
Mol Cell 2018; 71: 775-790