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Our research

We seek to understand how gene expression is regulatedOur lab applies genetics, biochemistry, high-throughput sequencing, and computational modeling to define the biological roles of RNA metabolism in development and disease.

Publications

Cleavage of mRNAs by a minority of pachytene piRNAs improves sperm fitness

Cecchini K, Zamani M, Ajaykumar N, Vega-Badillo J, Bagci A, Bailey S, Zamore PD, Gainetdinov I

Nature. 2026; in press

Absolute Quantification of Mammalian MicroRNAs for Therapeutic RNA Cleavage and Detargeting

Kraus C, Wang J, Zheng H, Broderick J, Ajaykumar N, Zamani M, Mengqi Y, Cecchini K, Liang SQ, Kolumba O, Chase K, Lee J, Xue W, Sontheimer E, Gainetdinov I

RNA. 2025; doi: 10.1261/rna.080566.125

Relaxed targeting rules help PIWI proteins silence transposons

Gainetdinov I, Vega-Badillo J, Cecchini K, Bagci A, Colpan C, De D, Bailey S, Arif A, Wu PH, MacRae IJ, Zamore PD

Nature. 2023; 619: 394–402

A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila

Venkei ZG*, Gainetdinov I*, Bagci A, Starostik MR, Choi CP, Fingerhut JM, Chen P, Balsara C, Whitfield TW, Bell GW, Feng S, Jacobsen SE, Aravin AA, Kim JK, Zamore PD, Yamashita YM. *co-first authors

Nat Cell Biol. 2023; 25:1495–1505

Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability

Gainetdinov I, Colpan C, Cecchini K, Arif A, Jouravleva K, Albosta P, Vega-Badillo J, Lee Y, Özata DM, Zamore PD

Mol Cell. 2021; 81: 4826–4842

A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals

Gainetdinov I*, Colpan C*, Arif A, Cecchini K, Zamore PD. *co-first authors
Mol Cell. 2018; 71: 775-790

Contact us

Ildar Gainetdinov

Department of Biology

College of Arts and Science

New York University

Address:

29 Washington Place
7th Floor, Rm 753
New York, NY 10003

 

Tel: +1-212-998-3911

Email: ildar.gainetdinov@nyu.edu

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